منابع مشابه
Jaundice and factor VII deficiency in newborn
Resistance to thyroid hormone is an uncommon condition. We report the clinical and laboratory findings of a case with both resistance to thyroid hormone and, a reduced capacity to produce and respond to thyroid hormone. RTH is a disorder characterized by elevated circulating thyroid hormones, state of non-suppressed pituitary TSH secretion and refractoriness to hormone action in peripheral tiss...
متن کاملMarburg I polymorphism of factor VII-activating protease and risk of venous thromboembolism.
The factor VII–activating protease (FSAP), a newly discovered serine-protease present in human plasma, has 2 main functions in hemostasis: it is a potent activator of prourokinase1 and accelerates coagulation by activating factor VII, independently of tissue factor.2 The FSAP Marburg I polymorphism (1601G A) was recently evaluated as a candidate risk factor for venous thromboembolism (VTE), sin...
متن کاملMarburg I polymorphism of factor VII-activating protease and risk of recurrent venous thromboembolism.
Whether a single nucleotide polymorphism (1601 G > A) in the factor VII-activating protease gene (FSAP Marburg I) is a risk factor for venous thromboembolism (VTE) is unclear. We investigated the relevance of the variant with respect to recurrentVTE. 854 patients with a first unprovoked VTE were followed for an average of 41 months after discontinuation of anticoagulation. Study endpoint was sy...
متن کاملPreparation of factor VII concentrate using CNBr-activated
Background: Factor VII concentrates are used in patients with congenital or acquired factor VII deficiency or treatment of hemophilia patients with inhibitors. In this research, immunoaffinity chromatography was used to purify factor VII from prothrombin complex (Prothrombin-Proconvertin-Stuart Factor-Antihemophilic Factor B or PPSB) which contains coagulation factors II, VII, IX and X. The a...
متن کاملMarburg I polymorphism of factor VII-activating protease is associated with idiopathic venous thromboembolism.
The factor VII-activating protease (FSAP) variant Marburg I is known to attenuate the profibrinolytic system in vitro and was recently shown to be a significant predictor for the evolution and progression of carotid stenosis. The objective of this case-control study was to assess FSAP Marburg I's role in the occurrence of venous thromboembolism (VTE). The frequency of FSAP Marburg I was signifi...
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ژورنال
عنوان ژورنال: Acta Haematologica
سال: 1984
ISSN: 0001-5792,1421-9662
DOI: 10.1159/000206416